Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia.
Sirtuin 1 (Sirt1) has been reported to be a critical positive regulator of glucose-stimulated insulin secretion in pancreatic beta-cells.The effects on islet cells and blood glucose levels when Sirt1 RED CHESTNUT is deleted specifically in the pancreas are still unclear.This study examined islet glucose responsiveness, blood glucose levels, pancrea